Repatha cholesterol injection -Developed by Amgen, Repatha (evolocumab) was approved by the FDA in 2015 to lower LDL-C and Non-HDL-C, as well as ApoB, in patients with primary hypercholesterolemia or mixed dyslipidemia who have been treated with maximally tolerated statin therapy, including high dose atorvastatin. Patients who received the injection for 6 months had their LDL cholesterol significantly reduced compared to those who received placebo injections. This will likely make Repatha an attractive option for many people struggling with cholesterol disorders.
What is Repatha?
Repatha is a prescription drug that targets the root cause of high cholesterol, whereas many other pharmaceuticals only address symptoms. A regimen of one injection every two weeks reduces LDL cholesterol by 10 percent at three months and 25 percent at one year without serious side effects.
Repatha targets PCSK9 molecules that reduce LDL levels and does not come with the same risk of side effects as statins such as myopathy, and muscular or hepatic disorders.
Side effects may include respiratory tract infections and hypersensitivity reactions, but these have been found to be less common than those associated with traditional pharmaceuticals. Results show patients achieving a target level of below 100 mg/dL in just 30 days.
What are the benefits of taking
Benefits of taking Repatha?
-Reduce the risk of heart attack, stroke, or death -Treat high cholesterol -No reaction occurred when injecting generic cholesterol medication names -No serious allergic reactions -Pushtronex system prefilled syringes ensure easy use and sterile injection of repatha -Doctors and pharmacists may be able to help you administer injections if you don’t have a prescription from your doctor.
What does Repatha injection do?
The new injectable cholesterol medication, called repatha or evolocumab, is designed to reach as many high-risk patients as possible with a proven solution.
A low-cost generic will be coming out in 2018, but it has not been studied as extensively in clinical trials. Doctors have more experience with repatha and know it works effectively.
In the phase 3 FOURIER trial of 18,000 high-risk patients with preexisting cardiovascular disease or type 2 diabetes mellitus without cardiovascular disease.
Statin therapy reduced the incidence of coronary heart disease by one quarter and stroke by one-third over 4 years for those who were treated with repatha plus standard of care.
How does it work?
PPCSK9 inhibitors are a new class of medication that lowers LDL cholesterol, also known as bad cholesterol.
By binding with and inhibiting the protein PCSK9, they prevent it from signaling the liver cells to produce more LDL cholesterol. On May 18th, 2015, the FDA approved a PPCSK9 inhibitor made by Amgen called Repatha (re-PAY-ta) or evolocumab.
Unlike statins that inhibit an enzyme that makes the liver produce LDL cholesterol, the 140 mg injection once every two weeks works in a totally different way by interfering with production at its root cause and has been shown to be more effective than statins in treating patients with high levels of bad cholesterol.
How long does a Repatha injection last?
Repatha is injected once every two weeks. After the first two injections, most people need injections only every 4 weeks or 6 months. The infusion will lower cholesterol by turning off the gene that makes cholesterol and reducing liver production of LDL-cholesterol, a type of bad cholesterol. Side effects include allergic reactions (less than 1%), joint pain, muscle pain, pain in extremities (less than 2%), and skin itching.
Best time of day to take repatha
Repatha an injectable drug used to lower LDL cholesterol. Your doctor may prescribe this medication based on your risk for heart disease but will review with you how and when you should take it. There no solid guidelines for how much time allowed between taking a dose. The next one, so in general, it’s best if you wait at least 8 hours before taking another dose. With any medication, you’ll want to follow your doctor’s instructions exactly and read the prescription insert carefully too.
##Most people take their first injection at home, but many doctors like them to have someone around to answer questions.
Before you start using Repatha
Just because you are having trouble getting your cholesterol under control, don’t lose hope. There a new FDA-approved injection called Repatha. The generic name evolocumab may help get it back down where it needs to be.
This latest medication the first of it kind and designed to lower LDL. Bad cholesterol by up to 60%. It a once-a-month injection that shown in studies to safely lower LDL by up to 55%. From just one shot without causing any major side effects.
So if you’ve had problems getting your cholesterol down using other medications in the past, this could be worth looking into for an alternative solution.
What makes it different from other medications?
Repatha the newest member of a new class of drugs called pcsk9 inhibitors. Research has shown that these drugs can lower bad cholesterol by up to 46%.
It shown in clinical trials that these medications have few side effects. People who take them generally have better blood lipid levels. Less chance of heart attack, and a lower risk for stroke than those on a placebo.
Because they pretty new, not many doctors are familiar. With this kind of treatment but as more data collected. More doctors become knowledgeable about the drug and its use cases. It should grow in popularity.
Repatha treats high cholesterol caused by a condition called Familial Hypercholesterolemia or FH.
How long does it take Repatha to lower cholesterol?
Patients who received treatment with evolocumab as a monotherapy or combination therapy with other lipid-lowering. Medications experienced significant reductions in LDL-C at week 12 from baseline. These reductions corresponded to an average reduction of 34% across all doses. Even after 24 weeks, LDL-C levels continued to decrease by 5% on average.
Cholesterol Reduction at Week 12 with Evolocumab. As Monotherapy or Combination Therapy -34% at 1 milligram -42% at 2 milligrams -46% at 3 milligrams -49% at 4 milligrams
Will it make me tired or sick? – Repatha cholesterol injection
Repatha is one of the newest cholesterol medications on the market, but also one of the most effective. There are a number of common side effects that you may experience, but with just about all cholesterol treatments there will be some kind of reaction to the medication. Most people who try Repatha will notice their blood glucose levels increasing and those who have kidney problems should avoid taking this drug because it can damage their kidneys. Other common side effects include muscle pain or weakness, nausea, and joint pain.
What is the side effects of Repatha?
Repatha is a cholesterol-lowering medication that works differently than other drugs. Rather than just reducing the total amount of LDL cholesterol in your blood, it inhibits the liver from making the substance your body needs to make LDL.
This can reduce the rate at which plaques develop in the artery walls, and shrink those that already exist. As with any drug, their potential side effects associated with taking Repatha. It should not taken by people. Who has had an allergic reaction to another drug in this class? An antibody such as ezetimibe/simvastatin/gemfibrozil or who have type 1 diabetes.